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Man Shot Dead By Police After Stabbing, City Streets In Lockdown

Police have shot and killed a man in Brisbane's city centre after he allegedly stabbed one person and charged at officers.

Parts of the city's CBD remain in lockdown on Sunday afternoon.

Police received reports a man stabbed another in Mary Street, in the heart of the city, around 10am on Sunday. Officers responded to the scene, responding to reports a man was armed with a knife.

"It will be alleged the man charged at officers and was critically injured when police returned fire," QLD Police said in a statement.

The man was pronounced dead at the scene. The 26-year-old stabbing victim was taken to hospital with injuries to his face and back.

Authorities urged people to avoid Mary Street and Edward Street in the city, which remained in lockdown.

"We can confirm we have multiple resources on scene and assessing two patients," a spokesperson for the Queensland Ambulance Service told 10 daily.

Queensland Police issued a warning to the public just after 11am today.

Some witnesses reported hearing at least six shots while reports from the suggest that the man was allegedly holding a knife and had stabbed another man.

Authorities are yet to verify those reports.

"Police responded to disturbance this morning and as a result we have multiple crime scenes," a police spokesperson told 10 daily.

One person replied to the Tweet saying the "response to this event was impressive...never seen this many police cars and ambulances appear in minutes...".

A guest of the Westin Hotel told AAP she heard several gunshots, but thought they were fireworks.

"I came outside and I saw someone lying on the ground and (police) were performing CPR," she said.

More to come.